i do it all the time.you can catch just about anything on a fly.i use small poppers or chartreuse nymphs for crappies,bluegills.black leech patterns or foam frogs for bass,i've had carp hit flies(all different ones).a good all around fish pattern is a black or olive size 8 wooly bugger.
I was planning on tying some clousers, for targeting pickerel. I usually tie a light bottom, darker topside, with some flash in between. When doing the black clouser do you go totally black? What size hooks and what length do you suggest?
Yup, all black. Or dark black on top and a slightly lighter black/dark gray on bottom. Use a longer shanked hook for picks, like a 3X+ streamer hook. For the same reason you would use a longer hook for blues. All black with bead-chain eyes usually works very well around drop offs and deep weed lines. You can get a nice slow hop. Sometimes it doesn't hurt to put on a mono weed guard, too.