On my 30tws I use 50lb mono. I have them set at about 15-16lbs at strike. When trolling, I usually have them a little below strike. I would guess between 10-12lbs. When we hook up, I adjust as needed. Usually I wait until the fish slows down, then I push it up to strike. If line capacity becomes an issue, push it up right away. For multiples, just be aware of this line capacity. Like Warden said, you will have to keep trolling after the first is hooked up. I would say that if you don't hook up another within 30 seconds or so, you probably wont. Other's will disagree I am sure, but at that point line capacity can start becoming an issue for me!